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Circulating CD31+/Annexin V+ microparticles correlate with cardiovascular outcomes

Jan-Malte Sinning1, Jan Losch, Katrin Walenta

  • 1Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

European Heart Journal
|December 28, 2010
PubMed

Insights

Elevated CD31+/Annexin V+ microparticles (MPs) predict cardiovascular events in patients with stable coronary artery disease (CAD). These microparticles may improve risk assessment for major adverse cardiovascular and cerebral events (MACCE).

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Clinical Research

Background:

  • CD31+/Annexin V+ microparticles (MPs) are elevated in individuals with cardiovascular risk factors and impaired endothelial function.
  • Previous studies suggest a link between MPs and endothelial dysfunction.

Purpose of the Study:

  • To determine if CD31+/Annexin V+ MPs serve as an independent predictor of cardiovascular events in patients with stable coronary artery disease (CAD).
  • To assess the utility of MPs in cardiovascular risk stratification for CAD patients.

Main Methods:

  • Flow cytometry was used to quantify CD31+/Annexin V+ MP levels in 200 stable CAD patients.
  • Patients were followed for a median of 6.1 years for major adverse cardiovascular and cerebral events (MACCE).
  • Multivariate analysis was performed, adjusting for traditional cardiovascular risk factors.

Main Results:

  • Higher MP levels were observed in patients who experienced MACCE compared to those who did not (P=0.004).
  • Elevated MP levels were independently associated with increased risk of cardiovascular death (HR 4.0), revascularization (HR 2.4), and first MACCE (HR 2.3).
  • Inclusion of MP levels improved the predictive accuracy of a traditional cardiovascular risk model (c-statistic increased from 0.637 to 0.702).

Conclusions:

  • Circulating CD31+/Annexin V+ MPs are an independent predictor of cardiovascular events in stable CAD.
  • MP levels may enhance the risk stratification of patients with stable coronary artery disease.
Abstract

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