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Updated: Jun 5, 2026
Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
Published on: March 17, 2008
Design of an in-dwelling cannula for convection-enhanced delivery
Kathryn H Rosenbluth1, Matthias Luz, Erich Mohr
1Department of Neurosurgery, University of California San Francisco, 1855 Folsom St, MCB226, San Francisco, CA 94103-0555, USA.
Abstract:
Failures of recent convection-enhanced delivery (CED) trials have underscored the need for improved CED cannulae. This study presents a novel in-dwelling cannula targeted for use in upcoming neuro-oncological or neurodegeneration trials. The cannula is reflux-resistant and easily integrated into clinical workflows. The cannula was evaluated in non-human primate CED studies performed with magnetic resonance imaging (MRI) to validate the effectiveness and safety of the infusion.
