Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
Auditory Pathway01:15

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
Auditory Perception01:17

Auditory Perception

The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the cochlea, a...
Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The occurrence of Bacillus botulinus, types A and B, in accidental wounds.

Journal of bacteriology·2010
Same author

The ambiguity of international antitoxic units.

Science (New York, N.Y.)·2010
Same author

THE INFLUENCE OF CALCIUM CHLORIDE UPON EXPERIMENTAL BOTULISM.

The Journal of experimental medicine·2009
Same author

A matter of focus: monoaminergic modulation of stimulus coding in mammalian sensory networks.

Current opinion in neurobiology·2004
Same author

Serotonergic innervation of the auditory brainstem of the Mexican free-tailed bat, Tadarida brasiliensis.

The Journal of comparative neurology·2001
Same author

Serotonin effects on frequency tuning of inferior colliculus neurons.

Journal of neurophysiology·2001
Same journal

TGF-β signaling regulates flat epithelium formation in severely injured adult mouse utricle through epithelial-mesenchymal transition.

Hearing research·2026
Same journal

Membrane scaffolding in auditory hair cells - a molecular tightrope walk enables lateral wall stiffness and flexibility.

Hearing research·2026
Same journal

Speech-in-noise recognition during hearing protector use: Human performance and acoustic prediction.

Hearing research·2026
Same journal

Estimation of hair cell loss from audiograms.

Hearing research·2026
Same journal

Cochlear size variation in a large-scale international multicentre cohort.

Hearing research·2026
Same journal

Estimation of minor-to-moderate conductive hearing loss with distortion-product otoacoustic emissions in humans.

Hearing research·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
08:49

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

Context-dependent modulation of auditory processing by serotonin.

L M Hurley1, I C Hall

  • 1Indiana University, Jordan Hall/Biology, 1001 E. Third St, Bloomington, IN 47405, USA. lhurley@indiana.edu

Hearing Research
|December 29, 2010
PubMed
Summary
This summary is machine-generated.

Serotonin modulates auditory processing by altering neural responses based on behavioral state. This neuromodulator influences auditory plasticity, impacting how the brain processes sound in various contexts.

Related Experiment Videos

Last Updated: Jun 5, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
08:49

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Neuropharmacology

Background:

  • Auditory processing exhibits context-dependent plasticity, influenced by behavioral states.
  • Serotonin, a neuromodulator, is well-positioned to mediate these state-dependent changes in the auditory system.

Purpose of the Study:

  • To explore the role of serotonin in regulating auditory processing plasticity.
  • To understand how serotonin influences neural responses to sound based on behavioral context.

Main Methods:

  • Investigated the projections of serotonergic neurons to auditory regions.
  • Examined the effects of serotonin on auditory neuron intrinsic and synaptic properties.
  • Analyzed serotonin's impact on short- and long-term plasticity in the auditory system.

Main Results:

  • Serotonin release in the auditory system increases during heightened arousal and specific events (stressful, social).
  • Serotonin exerts specific effects via localized projections and diverse receptor subtypes on auditory neurons.
  • Serotonin alters auditory neuron responses and both short- and long-term plasticity.

Conclusions:

  • Serotonin acts as a widespread mechanism for behaviorally relevant plasticity in auditory processing.
  • The serotonergic system's plasticity adapts to factors like age and cochlear trauma.
  • This regulatory mechanism may have implications for pathological auditory processing.