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Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Drug Toxicity: Risk factors

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Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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Prescription, Nonprescription and Orphan Drugs

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Opioid Analgesics: Morphine and Other Natural Cogeners

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Related Experiment Video

Updated: Jun 5, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Analgesic prescribing errors and associated medication characteristics.

Howard S Smith1, Timothy S Lesar

  • 1Department of Anesthesiology, Albany Medical Center, 43 New Scotland Avenue, Albany, NY 12208, USA.

The Journal of Pain
|December 29, 2010
PubMed
Summary
This summary is machine-generated.

Medication errors with analgesics are common, especially in children. Specific drug characteristics like multiple dosage forms and atypical regimens significantly increase the risk of these preventable patient safety events.

Related Experiment Videos

Last Updated: Jun 5, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Area of Science:

  • Pharmacology
  • Patient Safety
  • Health Services Research

Background:

  • Medication errors involving analgesics are a significant cause of poor treatment outcomes and adverse events.
  • Prescribing mistakes are a major concern in analgesic administration.

Purpose of the Study:

  • To systematically evaluate prevented analgesic prescribing errors (near-misses) in a teaching hospital.
  • To identify analgesic medication characteristics that contribute to prescribing errors.

Main Methods:

  • Systematic evaluation of 2,044 prevented analgesic prescribing errors.
  • Analysis of error rates based on drug, dosage form, route of administration, and patient population.

Main Results:

  • The overall detected error rate was 2.87 errors per 1,000 analgesic orders.
  • Pediatric patients had more than double the error rate of adult patients.
  • Factors contributing to 40% of errors included multiple dosage forms, modified dosages, atypical regimens, sound-alike names, and scheduled use.

Conclusions:

  • Specific analgesic product characteristics and usage patterns are linked to increased error risk.
  • Findings can inform patient education and medication safety strategies to mitigate risks associated with analgesic errors.