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Oxaliplatin-induced pancreatitis: a case series
Waseem Butt1, Hamid Saadati, Muhammad Wasif Saif
1Department of Medicine, Wright State University, Dayton, OH 10032, USA. mws2138@columbia.edu
Anticancer Research
|December 29, 2010
Summary
Oxaliplatin, a chemotherapy drug, has been linked to acute pancreatitis in a series of six cases. Stopping oxaliplatin treatment led to symptom resolution, highlighting its potential role in drug-induced pancreatitis.
Area of Science:
- Oncology
- Gastroenterology
- Pharmacology
Background:
- Drug-induced pancreatitis is a rare complication, accounting for 0.1%–2% of acute pancreatitis cases.
- Oxaliplatin, an alkylating agent, has not been previously associated with acute pancreatitis.
Purpose of the Study:
- To investigate the potential association between oxaliplatin and acute pancreatitis.
- To report a series of cases of acute pancreatitis in patients treated with oxaliplatin.
Main Methods:
- A case series of six patients with gastrointestinal malignancies treated with oxaliplatin-based chemotherapy.
- Exclusion of other causes of acute pancreatitis before attributing it to oxaliplatin.
Main Results:
- All six patients developed acute pancreatitis during oxaliplatin treatment.
- Discontinuation of oxaliplatin resulted in the resolution of pancreatitis symptoms and normalization of serum amylase and lipase levels.
Conclusions:
- Oxaliplatin should be considered a potential cause of acute pancreatitis in patients undergoing chemotherapy.
- Early diagnosis and treatment are crucial for managing oxaliplatin-induced pancreatitis.
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