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Pemetrexed-induced eyelid edema: incidence and clinical manifestations
D Schallier1, L Decoster, C Fontaine
1Department of Medical Oncology, Oncologisch Centrum, UZ Brussel, 1090 Brussels, Belgium. denis.schallier@uzbrussel.be
Background:
Pemetrexed-induced eyelid edema is a rare side-effect of pemetrexed treatment.
Patients And Methods:
Retrospective analysis of the incidence and severity of eyelid edema was conducted in patients treated with pemetrexed in a single institution.
Results:
Eighty-six patients received pemetrexed-containing chemotherapy either as a single agent (45 patients) or in combination with cis- or carboplatin (41 patients). Two patients (2.3%) with stage IV non-small cell lung cancer (NSCLC) presented the edema typically localized in the lower eyelid after first-line treatment with carboplatin-pemetrexed. The edema remained identical in both patients during treatment and regressed in one patient in whom treatment was withdrawn. No other localizations of edema were observed in these patients.
Conclusion:
Pemetrexed-induced eyelid edema may be more frequent than originally reported. The physiopathological mechanism and, as a consequence, the treatment and/or prevention of this apparently benign side-effect remains unknown.
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