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Related Experiment Video

Updated: Jun 5, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

[Bazedoxifene as a new-generation SERM].

¹International University of Health and Welfare/Sanno Medical Center, Women's Medical Center.

Clinical Calcium

|December 29, 2010

Summary

This summary is machine-generated.

Bazedoxifene, a novel selective estrogen receptor modulator (SERM), significantly reduces vertebral and non-vertebral fractures in postmenopausal osteoporosis. It offers a favorable safety profile, making it a promising new treatment option.

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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

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Published on: August 13, 2019

Area of Science:

Pharmacology
Endocrinology
Bone Metabolism

Context:

Postmenopausal osteoporosis poses a significant fracture risk.
Selective estrogen receptor modulators (SERMs) are used for osteoporosis treatment.
Bazedoxifene represents a new generation SERM with a novel chemical structure.

Purpose:

To evaluate the efficacy and safety of bazedoxifene for treating postmenopausal osteoporosis.
To compare bazedoxifene's effects on bone, lipid profile, and tissue safety with existing treatments.

Summary:

Bazedoxifene demonstrated a 42% reduction in new vertebral fractures in a Phase III trial, comparable to bisphosphonates and raloxifene.
A post-hoc analysis indicated bazedoxifene may be more effective than raloxifene in reducing non-vertebral fractures in high-risk individuals.
Bazedoxifene showed a favorable safety profile, with no significant differences in major cardiovascular events or mortality.
Adverse events like VTEs, hot flushes, and leg cramps were similar to raloxifene, a known class effect of SERMs.

Impact:

Bazedoxifene is poised to become a key therapeutic option for postmenopausal osteoporosis in Japan.
The drug's efficacy in fracture reduction and favorable safety profile support its clinical utility.
Further research may elucidate bazedoxifene's specific advantages in non-vertebral fracture prevention.