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Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
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Synthesis and Functions of Calcitonin

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EDTA: Indirect and Alkalimetric Titration

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Related Experiment Video

Updated: Jun 5, 2026

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
08:53

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

[Eldecalcitol (ED-71)].

Itsuro Endo1, Toshio Matsumoto

  • 1Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences.

Clinical Calcium
|December 29, 2010
PubMed
Summary
This summary is machine-generated.

ED-71, a novel vitamin D analog, enhances bone mass and strength in osteoporotic subjects by inhibiting bone resorption. This new vitamin D therapy shows anti-fracture efficacy, potentially outperforming alfacalcidol.

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Orthopedics

Background:

  • Vitamin D is crucial for bone health.
  • Osteoporosis leads to increased fracture risk.
  • Novel vitamin D receptor ligands are needed for improved osteoporosis treatment.

Purpose of the Study:

  • To evaluate the efficacy of ED-71, a novel vitamin D receptor ligand, in preclinical and clinical models of osteoporosis.
  • To assess ED-71's effects on bone mineral density, bone resorption, and bone formation.
  • To compare ED-71's osteoprotective effects with alfacalcidol.

Main Methods:

  • Preclinical studies in ovariectomized rats to assess bone mass and strength.
  • A randomized, placebo-controlled, double-blinded clinical trial in osteoporotic subjects.
  • Measurement of bone mineral density at lumbar vertebrae and hip.
  • Assessment of vitamin D status.

Main Results:

  • ED-71 increased vertebral bone mass and strength in ovariectomized rats by inhibiting bone resorption and maintaining bone formation.
  • In osteoporotic subjects, ED-71 significantly increased lumbar vertebral and hip bone mineral density, irrespective of vitamin D status.
  • ED-71 demonstrated a potentially superior osteoprotective effect compared to alfacalcidol.

Conclusions:

  • ED-71 is an effective novel vitamin D receptor ligand for treating osteoporosis.
  • ED-71 enhances bone mineral density and strength while inhibiting bone resorption.
  • ED-71 represents a promising new generation of active vitamin D with anti-fracture efficacy for osteoporotic patients.