Isolation and characterization of a process impurity in tizanidine hydrochloride
E K S Vijayakumar1, V G Gore, A Mahajan
1Mylan India Pvt. Ltd., Plot 1A/2, M.I.D.C. Industrial Estate, Taloja - 410 208, India.
Abstract:
A new process impurity was detected during the HPLC analysis of Tizanidine hydrochloride (I) batches. The impurity (II) was isolated by preparative HPLC and characterized by NMR and Mass spectral analysis as 5-S-ethyl-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride.
More Related Videos
09:16Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method
Published on: May 12, 2023
10:47Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
Published on: February 3, 2015
Related Concept Videos
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence
Therapeutic Drug Monitoring: Drug Analysis Methods
