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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: Jun 5, 2026

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

MicroRNAs and Multiple Sclerosis.

Kemal Ugur Tufekci1, Meryem Gulfem Oner, Sermin Genc

  • 1Department of Neuroscience, Health Science Institute, Dokuz Eylul University, Inciralti, 35340 Izmir, Turkey.

Autoimmune Diseases
|December 29, 2010
PubMed
Summary

MicroRNAs (miRNAs) regulate gene expression and immunity. Dysregulation of these small molecules is linked to autoimmune diseases like multiple sclerosis (MS), offering potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Immunology
  • Neuroscience

Background:

  • MicroRNAs (miRNAs) are noncoding RNAs regulating gene expression post-transcriptionally.
  • miRNAs play critical roles in immune cell development, activation, and function.
  • Aberrant miRNA expression is implicated in the development of autoimmune diseases.

Purpose of the Study:

  • To review miRNA biogenesis, function, and their roles in immunity and autoimmunity.
  • To focus on the emerging role of miRNAs in multiple sclerosis (MS) pathogenesis.
  • To discuss the potential of miRNAs as biomarkers and therapeutic targets for MS.

Main Methods:

  • Literature review of current research on miRNAs in immunity and autoimmunity.
  • Analysis of studies investigating miRNA expression patterns in multiple sclerosis.

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  • Synthesis of data on miRNA-mediated immune modulation in the central nervous system.

    • Main Results:

    • miRNAs are key regulators of immune responses, influencing both peripheral immunity and neuroinflammation.
    • Specific miRNA expression patterns are altered in multiple sclerosis patients.
    • miRNAs demonstrate potential for modulating immune responses in MS.

    Conclusions:

    • Understanding miRNA dysregulation in MS is crucial for elucidating disease pathogenesis.
    • miRNAs hold promise as diagnostic biomarkers for MS.
    • miRNAs represent a novel therapeutic avenue for multiple sclerosis treatment.