Related Experiment Video

Updated: Jun 5, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Early bifrontal brain injury: disturbances in cognitive function development

Christine Bonnier1, Aurélie Costet, Ghassan Hmaimess

  • 1Service de Neurologie Pédiatrique, Centre Neurologique William Lennox, Cliniques Saint-Luc, Université catholique de Louvain, Avenue Hippocrate, 10/1067, Ottignies-Louvain-la-Neuve, 1200 Bruxelles, Belgium.

Neurology Research International
|December 29, 2010
PubMed

Insights

Severe bifrontal traumatic brain injury (TBI) in early childhood disrupts cognitive development. Executive functions are crucial for other cognitive skills, impacting language and visuospatial abilities.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatric Neurology

Background:

  • Traumatic brain injury (TBI) in early childhood can have profound effects on neurodevelopment.
  • Frontal lobe injuries are particularly concerning due to their role in executive functions and higher-order cognition.
  • Understanding the long-term sequelae of pediatric TBI is crucial for intervention and rehabilitation.

Observation:

  • A case study details sequential developmental evaluations of a boy with severe bifrontal TBI sustained at 19 months.
  • The evaluations tracked psychomotor, language, and neuropsychological development over time.
  • Specific deficits in visuospatial, drawing, writing, and language skills (reading, spontaneous speech) were observed.

Findings:

  • Early-onset bifrontal TBI led to abnormal development of visuospatial, drawing, and writing abilities.
  • Progressive language difficulties, including reading and spontaneous speech impairments, emerged over time.
  • Later evaluations revealed significant executive function deficits in inhibition, cognitive flexibility, and working memory.

Implications:

  • Early frontal lobe brain injury can significantly disorganize the developmental trajectory of cognitive functions.
  • Executive functions play a critical role in the development and interaction of other cognitive domains.
  • These findings highlight the interconnectedness of cognitive development and the impact of early brain injury on this process.

More Related Videos

Detecting Behavioral Deficits in Rats After Traumatic Brain Injury07:54

Detecting Behavioral Deficits in Rats After Traumatic Brain Injury

Published on: January 30, 2018

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the cerebellum's...
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...