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[Bacteriologic study of lung infection in 47 cases of burns]
1304th Hospital, PLA, Beijing.
Abstract:
The culture results of sputum (SP), blood (BL) and wound secretions (WS) of 47 cases of burns with lung infection were analyzed. Symptoms of pneumonia within 5 days after burn were observed in 90.3% of inhalation injury patients (IIG, 31 cases) whereas only in 25.0% of noninhalation injury patients (NIIG, 16 cases). The isolation rates of Gr(-) bacteria from the 3 sources of culture were markedly higher than those of Gr(+) cocci. The same bacteria, mainly Ps. aeruginosa and Staph. aureus, were identified simultaneously from the 3 sources of culture in 12 cases (25.5%). Isolates from SP correlated well with those from WS, the coincidence rates of 4 main Gr(-) bacteria were over 58%. Ps. aeruginosa was the commonest pathogen of IIG but Staph. aureus was the commonest in SP and BL of NIIG. The isolation rate of fungi of SP in NIIG was about twice that in IIG. Ps. aeruginosa and E. coli were susceptible to Amikacin and Polymixin B, Ps. aeruginosa was more susceptible to Cefoperazone, while the Gr(+) cocci were susceptible to first generation Cephalosporins.
Insights
Lung infections in burn patients are often caused by Gram-negative bacteria, particularly Pseudomonas aeruginosa in inhalation injury cases. Antibiotic susceptibility varies, with specific drugs effective against different bacterial types.
Area of Science:
- Infectious Diseases
- Burn Care
- Microbiology
Background:
- Burn patients are susceptible to lung infections, with inhalation injury significantly increasing pneumonia risk.
- Gram-negative bacteria are prevalent pathogens in burn-related lung infections.
Purpose of the Study:
- To analyze the microbiological profiles and antibiotic susceptibility of lung infections in burn patients.
- To compare infection patterns between inhalation injury (IIG) and non-inhalation injury (NIIG) groups.
Main Methods:
- Analysis of sputum, blood, and wound secretion cultures from 47 burn patients.
- Identification of bacterial and fungal pathogens.
- Assessment of antibiotic susceptibility patterns.
Main Results:
- Pneumonia occurred in 90.3% of IIG patients vs. 25.0% of NIIG patients.
- Gram-negative bacteria, especially Pseudomonas aeruginosa, were more common than Gram-positive cocci.
- Pseudomonas aeruginosa was the most frequent pathogen in IIG, while Staph. aureus predominated in NIIG.
- High concordance of bacterial isolates was observed between sputum and wound cultures.
Conclusions:
- Lung infections in burn patients are polymicrobial, with Gram-negative bacteria being dominant.
- Inhalation injury is a major risk factor for early-onset pneumonia.
- Targeted antibiotic therapy based on pathogen identification and susceptibility is crucial for effective treatment.