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Published on: October 12, 2017
Hypercholesterolemia, oxidative stress and gender dependence in children
I Ondrejovičová1, J Muchová, C Mišľanová
1Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
Children with hypercholesterolemia exhibit elevated lipid profiles and increased oxidative stress markers. This study highlights the link between high cholesterol and oxidative damage in children, emphasizing early detection for preventing atherosclerosis.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Health
- Oxidative Stress Research
Background:
- Hypercholesterolemia (HCH) is a significant risk factor for atherogenesis.
- Oxidative stress and modified LDL play critical roles in HCH development.
- Atherosclerotic processes can begin in childhood, often before clinical symptoms manifest.
Purpose of the Study:
- To evaluate lipid profiles, lipophilic vitamins, antioxidants, and oxidative stress markers in children with HCH.
- To investigate the relationship between hypercholesterolemia and oxidative stress in pediatric populations.
- To determine the influence of gender on these metabolic and oxidative parameters in children.
Main Methods:
- Inclusion of children with elevated total cholesterol (>4.5 mmol/l).
- Assessment of lipid profiles, lipophilic vitamins (retinol, tocopherols, carotenoids), and antioxidants.
- Measurement of oxidative damage markers: lipoperoxides (LP) and 8-isoprostanes (8-iso).
- Evaluation of serum total antioxidant capacity (TEAC).
Main Results:
- Children with HCH showed significantly altered lipid profiles, with gender-dependent variations in HDL-cholesterol and triglycerides.
- A notable decrease in serum TEAC (approx. 19.64%) and a significant increase in LP (approx. 45.73%) were observed in HCH children.
- Statistically significant correlations were found between lipid parameters, vitamins, antioxidants, and oxidative stress markers (LP, 8-iso, TEAC).
Conclusions:
- Hypercholesterolemia in children is associated with increased oxidative stress.
- Gender influences lipid profiles and oxidative stress parameters in children with HCH.
- Early detection of HCH and oxidative stress in childhood is crucial for future atherosclerosis prevention strategies.
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