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A Protocol to Acquire the Degenerative Tenocyte from Humans
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Estrogen receptor expression in posterior tibial tendon dysfunction: a pilot study.

Jay T Bridgeman1, Yue Zhang, Henry Donahue

  • 1Department of Orthopaedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, USA.

Foot & Ankle International
|December 30, 2010
PubMed
Summary
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Estrogen receptors (ERα and ERβ) are present in posterior tibial tendon (PTT) and flexor digitorum longus (FDL) tendons. Their expression did not differ between healthy and diseased tendons or between male and female patients.

Area of Science:

  • Orthopedics
  • Endocrinology
  • Molecular Biology

Background:

  • Posterior tibial tendon dysfunction (PTTD) pathophysiology is not well understood.
  • Hormonal influences, particularly estrogen, are theorized to affect tendon health.
  • Estrogen receptors (ER) are found in other musculoskeletal tissues like the anterior cruciate ligament (ACL).

Purpose of the Study:

  • To investigate the presence and expression levels of estrogen receptors (ERα and ERβ) in posterior tibial tendon (PTT) and flexor digitorum longus (FDL) tendons.
  • To determine if ER expression differs between healthy and diseased tendons.
  • To explore potential gender-based differences in ER expression within these tendons.

Main Methods:

  • Pilot study involving eight patients undergoing PTT surgery.

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  • Harvesting of diseased PTT tendon samples, with healthy PTT and FDL tendons used as controls.
  • Quantification of ERα and ERβ transcripts using real-time RT-PCR on isolated RNA.

    • Main Results:

    • ERα and ERβ transcripts were consistently detected in all tendon samples.
    • No significant differences in ER expression were observed between diseased and control tendon samples.
    • No significant differences in ER expression were found between male and female patients.

    Conclusions:

    • Tenocytes in both PTT and FDL tendons express ERα and ERβ.
    • Both normal and diseased tendons from male and female patients express estrogen receptors.
    • While estrogen receptors are present, this study did not establish a direct link between their expression levels and PTT dysfunction or gender.