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Membranoproliferative glomerulonephritis in a postpartum woman with sickle cell disease
Tausif Zar1, Jayapriya Krishnaswamy, Harold T Yamase
1Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA. zarjr73@yahoo.com
Abstract:
Renal insufficiency occurs in a considerable proportion of patients with sickle cell disease. Common advanced glomerular lesions include focal segmental glomerulosclerosis and nonimmune membranoproliferative glomerulonephritis. Due to the paucity of data supporting an immune-mediated pathophysiology, anti-inflammatory and immunosuppressive therapies have not been successfully evaluated in such patients. We present a case of membranoproliferative glomerulonephritis in a postpartum patient with sickle cell disease, where treatment with steroids was helpful.
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