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Related Concept Videos

Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

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Glucagon-like Receptor Agonists

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Related Experiment Video

Updated: Jun 5, 2026

Biochemical Reconstitution of Steroid Receptor&#x2022;Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

[Glucocorticoids up-regulate human chorion 11beta-hydroxysteroid dehydrogenase type 1].

Ping He1, Gang Sun

  • 1Department of Physiology, Second Military Medical University, Shanghai 200433, China.

Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology
|December 31, 2010
PubMed
Summary

Glucocorticoids, via glucocorticoid receptor (GR) binding, increase 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) activity and expression in human chorionic trophoblasts, suggesting an intracrine mechanism.

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Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
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Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

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Biochemical Reconstitution of Steroid Receptor&#x2022;Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Molecular Biology

Context:

  • Human chorionic trophoblasts play a crucial role in placental function.
  • Glucocorticoid receptor (GR) signaling is vital for various physiological processes.
  • 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) modulates local glucocorticoid levels.

Purpose:

  • To investigate the co-localization of GR and 11beta-HSD1 in human chorionic trophoblasts.
  • To determine if glucocorticoids regulate the activity and expression of 11beta-HSD1.
  • To elucidate the mechanism of glucocorticoid action on 11beta-HSD1.

Summary:

  • 11beta-HSD1 and GR are co-expressed in human chorionic trophoblasts.
  • Dexamethasone significantly increased 11beta-HSD1 reductase activity and mRNA levels.
  • These effects were abrogated by the GR antagonist RU486, confirming GR mediation.
  • Glucocorticoids induce 11beta-HSD1 expression via GR binding, potentially through an intracrine pathway.

Impact:

  • This study reveals a novel regulatory mechanism of 11beta-HSD1 in placental cells.
  • Understanding this pathway may offer insights into glucocorticoid-dependent placental development and function.
  • Findings contribute to the broader understanding of intracrine signaling in reproductive endocrinology.