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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

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Published on: August 16, 2021

Novel technologies: A weapon against tuberculosis.

B N Vedha Hari1, Karuna Priya Chitra, Ramadevi Bhimavarapu

  • 1Department of Pharmacy, School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu, India.

Indian Journal of Pharmacology
|December 31, 2010
PubMed
Summary
This summary is machine-generated.

Novel nanotechnology drug delivery systems offer a promising approach to combat tuberculosis (TB). These advanced methods aim to improve treatment efficacy, reduce dosing frequency, and overcome multidrug resistance, enhancing patient care.

Keywords:
Nanotechnologypolymerstargeted sitetuberculosis

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Area of Science:

  • Pharmaceutical Sciences
  • Nanotechnology
  • Infectious Diseases

Background:

  • Tuberculosis (TB) remains a significant global health challenge, characterized by lengthy treatment regimens and high pill burdens that compromise patient compliance.
  • Poor adherence to TB pharmacotherapy is a primary driver of therapeutic failure and the emergence of multidrug-resistant strains.
  • Current anti-TB drug development faces challenges in overcoming resistance and reducing treatment duration.

Purpose of the Study:

  • To review the development of novel nanocarrier-based drug delivery systems for anti-TB agents.
  • To explore strategies for targeting TB infection sites and reducing dosing frequency.
  • To assess the potential of nanotechnology in improving TB treatment outcomes and patient adherence.

Main Methods:

  • Comprehensive literature review of microparticulate, encapsulation, and carrier-based drug delivery systems for anti-TB agents.
  • Analysis of nanotechnology applications in designing targeted and sustained-release formulations.
  • Evaluation of studies focusing on improved patient compliance and reduced dosing frequency.

Main Results:

  • Nanotechnology enables the development of advanced drug delivery systems, including microparticles and encapsulated formulations, for principal anti-TB agents.
  • These systems demonstrate potential for targeted delivery to infection sites and reduced dosing frequency, thereby improving patient adherence.
  • The reviewed approaches aim to enhance the efficacy of TB pharmacotherapy and combat multidrug resistance.

Conclusions:

  • Nanotechnology-based drug delivery systems represent a promising frontier in the development of more effective and patient-friendly tuberculosis treatments.
  • Targeted delivery and reduced dosing frequency are key advantages offered by these novel systems.
  • Further research and development in this area are crucial for overcoming the challenges associated with current TB therapy.