Related Experiment Video
Updated: Jun 5, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Reemergence of mumps
1Department of Pediatrics, Kwandong University College of Medicine, Goyang, Korea.
Abstract:
The mumps virus is a single-stranded, non-segmented, negative-sense RNA virus belonging to the Paramyxoviridae family. Mumps is characterized by bilateral or unilateral swelling of the parotid gland. Aseptic meningitis is a common complication, and orchitis is also common in adolescents and adult men. Diagnosis is based on clinical findings, but because of high vaccination coverage, clinical findings alone are not sufficient for diagnosis, and laboratory confirmation is needed. Mumps is preventable by vaccination, but despite high vaccination coverage, epidemics occur in several countries, including Korea. Many hypotheses are suggested for these phenomena. In this review, we investigate the reason for the epidemics, optimal methods of diagnosis, and surveillance of immunization status for the prevention of future epidemics.
Insights
Despite high vaccination rates, mumps virus outbreaks persist. This review examines mumps epidemics, optimal diagnostic methods, and immunization surveillance to prevent future outbreaks.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Mumps is a viral illness caused by the mumps virus (a Paramyxoviridae family member), presenting with parotid gland swelling.
- Common complications include aseptic meningitis and orchitis in males.
- High vaccination coverage necessitates laboratory confirmation for mumps diagnosis due to reliance on clinical findings.
Purpose of the Study:
- To investigate the reasons behind ongoing mumps virus epidemics.
- To identify optimal diagnostic strategies for mumps.
- To assess immunization surveillance for preventing future mumps outbreaks.
Main Methods:
- Literature review of mumps virus epidemiology.
- Analysis of diagnostic criteria and laboratory confirmation methods.
- Evaluation of vaccination and immunization surveillance data.
Main Results:
- Mumps virus outbreaks occur despite high vaccination coverage.
- Clinical diagnosis alone is insufficient; laboratory confirmation is crucial.
- Epidemics may be linked to vaccination effectiveness and surveillance gaps.
Conclusions:
- Understanding the drivers of mumps epidemics is essential.
- Improved diagnostic approaches and robust immunization surveillance are needed.
- Strategies to enhance vaccine effectiveness and coverage are critical for mumps prevention.
Related Concept Videos
Vaccinations
Chickenpox
Poliomyelitis
Viral Recombination
Infectious Diseases and Their Occurrence
Smallpox
