Related Experiment Video

Updated: Jun 5, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

Pulmonary hypertension in infants with bronchopulmonary dysplasia

Gi Beom Kim1

  • 1Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Korean Journal of Pediatrics
|December 31, 2010
PubMed

Insights

Monitoring for pulmonary hypertension (PH) is crucial in infants with bronchopulmonary dysplasia (BPD). Early detection and multi-modality treatment, including vasodilators, are vital for improving outcomes in these vulnerable patients.

Area of Science:

  • Neonatology
  • Pediatric Cardiology
  • Pulmonology

Background:

  • Increasing incidence of preterm infants and reduced gestational age contribute to higher rates of bronchopulmonary dysplasia (BPD).
  • Secondary pulmonary hypertension (PH) is a significant complication in BPD patients, leading to increased morbidity and mortality.

Purpose of the Study:

  • To emphasize the necessity of regular screening for PH in BPD patients.
  • To highlight the importance of early intervention and comprehensive treatment strategies for PH in BPD.

Main Methods:

  • Echocardiography for PH assessment.
  • Biomarker monitoring using B-type natriuretic peptide (BNP) or N-terminal-proBNP.
  • Review of current multi-modality treatment approaches for PH in BPD.

Main Results:

  • Regular monitoring using echocardiography and BNP/NT-proBNP is recommended for BPD patients with moderate to severe disease.
  • Early detection of PH allows for timely initiation of treatment.
  • Multi-modality treatment, including supportive care and pulmonary vasodilators, is essential for managing significant PH in BPD.

Conclusions:

  • Consistent monitoring for PH in BPD patients is critical for reducing associated morbidity and mortality.
  • Prompt and comprehensive treatment, encompassing vasodilators and underlying condition management, is mandatory for BPD patients with significant PH.

Keywords:
Brain natriuretic peptideBronchopulmonary dysplasiaEchocardiographyPulmonary hypertensionVasodilator

More Related Videos

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice08:02

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 19, 2013

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...