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Published on: June 20, 2018
Secondary renal amyloidosis in a 13-year-old girl with bronchiectasis
Eun Ae Yang1, Dong Won Lee, Myung Chul Hyun
1Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.
Abstract:
A 13-year-old girl was diagnosed with non-cystic fibrosis (CF)-related multifocal bronchiectasis accompanied by nephrotic-range proteinuria of unknown cause. On renal biopsy, there were many segmental homogeneous deposits of amyloid tissue with positive Congo red staining in the glomeruli and interstitium. On electron microscopy, relatively straight, non-branching, randomly arranged amyloid fibrils were showed in the mesangium of the glomeruli. These fibrils were approximately 10 nm in diameter, compatible with secondary amyloidosis. Her level of serum amyloid A was remarkably elevated. To our knowledge, this girl is the first case of secondary renal amyloidosis induced by bronchiectasis in Korean children.
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