Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pneumocoele sinus: Computed tomographic findings and surgical approach in a 2-year-old Cob filly.

Equine veterinary journal·2026
Same author

Developmental regulation of kinetochore phosphorylation determines mitotic fidelity.

bioRxiv : the preprint server for biology·2026
Same author

Female athlete representation in exercise-induced cardiac adaptation research: a systematic review and audit of the literature.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Countervailing effects of cyclin isoforms A and B during mitosis.

bioRxiv : the preprint server for biology·2026
Same author

Chromosome engineering to correct a complex rearrangement on Chromosome 8 reveals the effects of 8p syndrome on gene expression and neural differentiation.

Genome research·2026
Same author

A busy BOD1-y: the diverse functions of an intracellular signaling regulatory protein family.

Biochemical Society transactions·2025

Related Experiment Video

Updated: Jun 5, 2026

Chromosome Preparation From Cultured Cells
07:42

Chromosome Preparation From Cultured Cells

Published on: January 28, 2014

Chromosomes and cancer cells.

Sarah L Thompson1, Duane A Compton

  • 1Department of Biochemistry, Dartmouth Medical School, 405 Remsen Building, Hanover, NH 03755, USA.

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
|December 31, 2010
PubMed
Summary

Cancer cells exhibit genomic instabilities, including abnormal chromosome numbers (aneuploidy) via chromosomal instability (CIN) and structural rearrangements via chromosome structure instability (CSI). Targeting these instabilities may slow tumor growth.

More Related Videos

Fluorescence In Situ Hybridization on DNA Halo Preparations to Reveal Whole Chromosomes, Telomeres and Gene Loci
09:07

Fluorescence In Situ Hybridization on DNA Halo Preparations to Reveal Whole Chromosomes, Telomeres and Gene Loci

Published on: March 4, 2021

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
08:29

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Published on: May 14, 2018

Related Experiment Videos

Last Updated: Jun 5, 2026

Chromosome Preparation From Cultured Cells
07:42

Chromosome Preparation From Cultured Cells

Published on: January 28, 2014

Fluorescence In Situ Hybridization on DNA Halo Preparations to Reveal Whole Chromosomes, Telomeres and Gene Loci
09:07

Fluorescence In Situ Hybridization on DNA Halo Preparations to Reveal Whole Chromosomes, Telomeres and Gene Loci

Published on: March 4, 2021

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
08:29

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Published on: May 14, 2018

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Cancer cells frequently display abnormal chromosome numbers (aneuploidy) and large-scale structural rearrangements.
  • These chromosome aberrations stem from underlying genomic instabilities, specifically chromosomal instability (CIN) and chromosome structure instability (CSI).

Purpose of the Study:

  • To review recent advancements in understanding the mechanisms and consequences of CIN and CSI in cancer.
  • To highlight the potential of targeting these genomic instabilities for cancer therapy.

Main Methods:

  • Review of recent scientific literature on chromosomal instability (CIN) and chromosome structure instability (CSI).
  • Analysis of the mechanisms leading to aneuploidy and chromosomal rearrangements.
  • Examination of the phenotypic consequences and clinical relevance of these instabilities.

Main Results:

  • CIN leads to aneuploidy through persistent chromosome gain/loss.
  • CSI results in structural rearrangements due to improper DNA damage repair.
  • Both CIN and CSI are linked to advanced, invasive, and chemotherapy-resistant tumors.

Conclusions:

  • CIN and CSI, while mechanistically distinct, contribute to aggressive cancer phenotypes.
  • Targeting CIN and CSI presents a promising therapeutic strategy to impede tumor progression and enhance treatment efficacy.