Related Experiment Video
Updated: Jun 5, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Insipid diabetes as initial presentation of Wegener's granulomatosis]
Lorena Narvaez Ponce1, Judith Carrio, Enrique R Soriano
1Servicio de Clínica Médica, Hospital Italiano de Buenos Aires.
Abstract:
Wegener's granulomatosis is a granulomatous necrotizing vasculitis which predominantly affects the respiratory tract, kidney, and less frequently other organs such as the nervous system. The latter may occur in up to 54% of cases and when it does it is more frequently of the peripheral nerves. We present a 19 year old woman who commenced her disease with involvement of respiratory sinuses, lungs and kidney and who developed central insipid diabetes (CID) at onset. The CID persisted in spite of adequate response of the other organs and systems with immunosuppresor treatment. The development of CID in the context of vasculitis should suggest this as a possible mechanism.
Related Concept Videos
Type I Diabetes III: Clinical Manifestations
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type I Diabetes II: Pathophysiology
Type I Diabetes I: Introduction
Diabetes Insipidus I: Introduction
Diabetes: Symptoms, Diagnosis, and Complications