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Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage
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Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage

Published on: May 6, 2020

Sequence-specific ultrasonic cleavage of DNA

Sergei L Grokhovsky1, Irina A Il'icheva, Dmitry Yu Nechipurenko

  • 1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. grok@imb.ac.ru

Biophysical Journal
|December 31, 2010
PubMed
Summary

Ultrasonic DNA cleavage intensity depends on nucleotide sequence and fragment position. Specific sequences, particularly those with deoxycytidine, show enhanced cleavage rates, offering insights into genome dynamics.

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