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Related Experiment Video

Updated: Jun 5, 2026

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Microfluidic chip-based nanoelectrode array as miniaturized biochemical sensing platform for prostate-specific

Napat Triroj¹, Papot Jaroenapibal, Haibin Shi

¹Division of Engineering, Brown University, 182 Hope Street, Providence, RI 02912, USA.

Biosensors & Bioelectronics

|December 31, 2010

Summary

This summary is machine-generated.

This study presents a novel microfluidic biosensor chip featuring a nanoelectrode array for sensitive detection of prostate-specific antigen (PSA). The device achieves a low detection limit of 10 pg/mL, enabling early disease diagnosis.

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Area of Science:

* Nanotechnology and Biosensing
* Electrochemistry and Microfluidics

Background:

* Development of sensitive and specific biosensors is crucial for early disease detection.
* Microfluidic devices offer miniaturization and reduced sample volume requirements for electrochemical assays.

Purpose of the Study:

* To develop a microfluidic biosensor chip with an integrated nanoelectrode array.
* To investigate the voltammetric response of the nanoelectrode array in a nanoliter sample volume.
* To detect prostate-specific antigen (PSA) using an on-chip competitive immunoassay.

Main Methods:

* Fabrication of a 5x5 gold nanoelectrode array using focused-ion-beam milling and electrodeposition.
* Integration of the nanoelectrode array with a polydimethylsiloxane (PDMS) microchannel.
* Cyclic voltammetry for electrochemical characterization and competitive immunoassay for PSA detection.

Main Results:

* Achieved a two-order of magnitude increase in current density compared to microelectrodes.
* Demonstrated on-chip functionalization for prostate-specific antigen (PSA) detection.
* Determined a detection limit of approximately 10 pg/mL (270 fM) for PSA.

Conclusions:

* The developed microfluidic biosensor chip enables highly sensitive electrochemical detection of biomarkers.
* The nanoelectrode array design and microfluidic integration are effective for nanoliter-scale analysis.
* This platform holds potential for point-of-care diagnostics and early disease screening.