Related Experiment Video
Updated: Jun 5, 2026

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
Published on: March 11, 2022
Crystal forms of SK-3530.
Hyun-Ok Song1, Young-Taek Sohn
1College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea.
Two crystal forms of SK-3530 were identified and found to be physically stable. Form 2 exhibited a significantly higher dissolution rate than Form 1, indicating potential pharmaceutical advantages.
Area of Science:
- Solid-state chemistry
- Pharmaceutical sciences
Background:
- Polymorphism significantly impacts drug properties, including solubility and bioavailability.
- Understanding crystal forms is crucial for drug development and formulation.
Purpose of the Study:
- To investigate the existence and physical stability of SK-3530 polymorphs.
- To compare the dissolution profiles of different SK-3530 crystal forms.
Main Methods:
- Recrystallization was used to isolate two distinct crystal forms of SK-3530.
- Characterization involved differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), and thermogravimetric analysis (TGA).
- Physical stability was assessed under various relative humidity (RH) conditions, and dissolution rates were measured in pH 6.8 buffer.
Main Results:
- Two unique crystal forms of SK-3530 were successfully isolated and characterized.
- Both forms demonstrated good physical stability over one month at room temperature across different RH levels.
- Form 2 exhibited a significantly faster dissolution rate compared to Form 1 within the first 30 minutes.
Conclusions:
- SK-3530 exists in at least two distinct polymorphic forms with good physical stability.
- Form 2's superior dissolution profile suggests it may offer enhanced bioavailability for pharmaceutical applications.
More Related Videos
07:08Crystallization and In Situ Room Temperature Data Collection Using the Crystallization Facility at Harwell and Beamline VMXi, Diamond Light Source
Published on: March 8, 2024
11:48Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography
Published on: April 24, 2018
Related Concept Videos
Determination of Crystal Structures
Crystal Growth: Principles of Crystallization
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent – the...
Imperfections in Crystal Structure: Stoichiometric Point Defects
Crystal Density
Crystal Field Theory - Octahedral Complexes
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
Imperfections in Crystal Structure: Point, Line and Plane Defects