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Updated: Jun 5, 2026
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
[Keratoconus and corneal transplant clinical study]
María Luisa Ruiz-Morales1, Karla Verdiguel-Sotelo, Adriana Hernández-López
1Instituto Mexicano del Seguro Social, Distrito Federal, México.
Objective:
to determine the frequency and clinical characteristics of patients with keratoconus and a corneal transplant (CT) at an ophthalmology reference hospital.
Methods:
retrospective, cross-sectional, observational, descriptive study of 166 patients with diagnosis of keratoconus and CT.
Results:
average age of 37.59 years, 97 males (58.43%), 69 females (41.56%). The primarily affected eye was the left one (95 cases, 57 %). Coef C -0.01265. The age at the keratoconus diagnosis was between 20 and 29 years (77 cases, 46.40 %), with an average of 24.5 years. The most frequent signs and symptoms were blurred vision: 140 (84.33 %), itching: 100 (60.24 %), photophobia: 20 (12.04 %). Associated systemic diseases: Down Syndrome 2 cases, (1.20 %), asthma 6 cases (3.61 %), atopic dermatitis 14 cases (8.43 %), allergic rhinitis 10 cases (6.02 %). Related ocular diseases: allergic conjunctivitis 72 cases (43.47 %).
Conclusions:
There is strong association between the corneal microtrauma secondary to itching resulting from allergic processes and keratoconus. A timely diagnosis is of great importance to diminish the progression to corneal scarring requiring a CT.
