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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
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Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 5, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

[New breakthroughs in Oncodermatology].

L Mortier1

  • 1Clinique de Dermatologie, CHRU Lille, rue Michel Polonovski, 59037 Lille, France. laurent.mortier@chru-lille.fr

Annales De Dermatologie Et De Venereologie
|January 4, 2011
PubMed
Summary
This summary is machine-generated.

2010 marked a turning point in cancer treatment, especially for melanoma. New therapies like Ipilimumab and anti-RAF treatments demonstrated significant survival benefits, offering new hope for patients.

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Area of Science:

  • Oncodermatology
  • Dermatology
  • Oncology

Background:

  • Oncodermatology research saw numerous publications in 2010.
  • The focus was on advancements in skin cancer and lymphoma treatments.

Purpose of the Study:

  • To review and highlight key advancements in oncodermatology from October 2009 to October 2010.
  • To identify breakthroughs in melanoma and lymphoma treatment.

Main Methods:

  • Analysis of scientific articles published within a specific one-year period.
  • Focus on clinical trial results and therapeutic management strategies.

Main Results:

  • Melanoma treatment saw significant breakthroughs, including the first molecule (Ipilimumab) to improve overall survival.
  • Anti-RAF therapies also yielded spectacular results in melanoma treatment.
  • Encouraging results were reported for systemic treatments in lymphoma trials.

Conclusions:

  • 2010 represents a potential turning point in the therapeutic management of melanoma.
  • New systemic treatments show promise for lymphoma patients.
  • Advancements in oncodermatology offer renewed hope for improved patient outcomes.