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Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Infertility in Females

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Related Experiment Video

Updated: Jun 5, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Finasteride-associated male infertility.

Koji Chiba¹, Kohei Yamaguchi, Fuping Li

¹Division of Urology, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe, Japan.

Fertility and Sterility

|January 4, 2011

Summary

Finasteride (1-mg dose) use was associated with male infertility in a patient with pre-existing low sperm count. Discontinuing finasteride improved semen parameters, enabling less invasive fertility treatments.

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Area of Science:

Endocrinology
Reproductive Medicine
Pharmacology

Background:

Finasteride is a 5α-reductase inhibitor commonly prescribed for androgenic alopecia.
Male infertility affects a significant portion of the population, with multifactorial causes.
Semen parameters are crucial indicators of male reproductive health.

Observation:

A male patient with a history of oligospermia developed azoospermia while using 1-mg finasteride for androgenic alopecia.
The patient had been diagnosed with oligospermia five years prior to the current presentation.
Semen analysis revealed azoospermia during finasteride treatment.

Findings:

Discontinuation of finasteride led to immediate improvement in semen volume.
Sperm concentration increased to over 10 × 10^6/mL within 16 weeks of finasteride cessation.
The patient's improved semen parameters allowed for consideration of intrauterine insemination.

Implications:

Finasteride cessation can reverse drug-induced infertility and improve spermatogenesis.
Clinicians should consider finasteride's potential impact on male fertility, especially in patients with pre-existing semen abnormalities.
Evaluating and potentially discontinuing finasteride may be a viable strategy for infertile men on this medication.