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Updated: Jun 5, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke
Mohammad Al-Tamimi1, Elizabeth E Gardiner, Jim Y Thom
1Monash University, Melbourne VI, Australia. mohammad.al-tamimi@monash.edu
Background And Purpose:
Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding.
Methods:
We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects.
Results:
sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024).
Conclusions:
Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.
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