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Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy
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Golden retriever muscular dystrophy (GRMD): Developing and maintaining a colony and physiological functional

Joe N Kornegay1, Janet R Bogan, Daniel J Bogan

  • 1Department of Pathology and Laboratory Medicine and The Gene Therapy Center, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA. joe_kornegay@med.unc.edu

Methods in Molecular Biology (Clifton, N.J.)
|January 4, 2011
PubMed

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
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