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Can mean platelet volume predict coronary vasospasm?

Cheol Ung Choi1, Hong Seog Seo, Yun Kyung Kim

  • 1Cardiovascular Center, Korea University, Guro Hospital, Seoul, South Korea.

Platelets
|January 4, 2011
PubMed

Insights

High mean platelet volume (MPV), a measure of platelet activation, is linked to coronary vasospasm. This finding suggests MPV may serve as a valuable biomarker for predicting coronary vasospasm risk.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Mean platelet volume (MPV) reflects platelet production and activation.
  • The association between MPV and coronary vasospasm remains uninvestigated.
  • Coronary vasospasm is a significant cause of angina.

Purpose of the Study:

  • To investigate the relationship between MPV and acetylcholine (Ach)-induced coronary vasospasm.
  • To determine if MPV is an independent predictor of coronary vasospasm.

Main Methods:

  • A cohort of 696 patients undergoing coronary angiography and Ach-provocation tests were analyzed.
  • Patients were categorized into Ach-induced coronary vasospasm (n=183) and control (n=513) groups.
  • MPV levels were compared between groups, and multivariate analysis was performed.

Main Results:

  • MPV showed a negative correlation with platelet count (r=-0.289, p<0.001).
  • Patients with Ach-induced coronary vasospasm exhibited significantly higher MPV (9.03±1.37 fL) compared to controls (8.69±1.25 fL, p=0.002).
  • Elevated MPV independently predicted Ach-induced coronary vasospasm (OR=1.188, p=0.018).

Conclusions:

  • High mean platelet volume is an independent risk factor for Ach-induced coronary vasospasm.
  • MPV may serve as a potential biomarker for identifying patients at risk of coronary vasospasm.
  • Further research is warranted to explore the clinical implications of MPV in coronary artery disease.

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