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Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

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Published on: March 15, 2022

Can mean platelet volume predict coronary vasospasm?

Cheol Ung Choi¹, Hong Seog Seo, Yun Kyung Kim

¹Cardiovascular Center, Korea University, Guro Hospital, Seoul, South Korea.

|January 4, 2011

Summary

High mean platelet volume (MPV), a measure of platelet activation, is linked to coronary vasospasm. This finding suggests MPV may serve as a valuable biomarker for predicting coronary vasospasm risk.

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Area of Science:

Cardiology
Hematology
Biomarkers

Background:

Mean platelet volume (MPV) reflects platelet production and activation.
The association between MPV and coronary vasospasm remains uninvestigated.
Coronary vasospasm is a significant cause of angina.

Purpose of the Study:

To investigate the relationship between MPV and acetylcholine (Ach)-induced coronary vasospasm.
To determine if MPV is an independent predictor of coronary vasospasm.

Main Methods:

A cohort of 696 patients undergoing coronary angiography and Ach-provocation tests were analyzed.
Patients were categorized into Ach-induced coronary vasospasm (n=183) and control (n=513) groups.
MPV levels were compared between groups, and multivariate analysis was performed.

Main Results:

MPV showed a negative correlation with platelet count (r=-0.289, p<0.001).
Patients with Ach-induced coronary vasospasm exhibited significantly higher MPV (9.03±1.37 fL) compared to controls (8.69±1.25 fL, p=0.002).
Elevated MPV independently predicted Ach-induced coronary vasospasm (OR=1.188, p=0.018).

Conclusions:

High mean platelet volume is an independent risk factor for Ach-induced coronary vasospasm.
MPV may serve as a potential biomarker for identifying patients at risk of coronary vasospasm.
Further research is warranted to explore the clinical implications of MPV in coronary artery disease.