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Cytokine crosstalk for thymic medulla formation

Takeshi Nitta1, Izumi Ohigashi, Yasushi Nakagawa

  • 1Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan.

Current Opinion in Immunology
|January 4, 2011
PubMed
Summary

Bidirectional signaling between thymocytes and medullary thymic epithelial cells (mTECs) is vital for immune tolerance. This cellular crosstalk shapes the thymic medulla, ensuring the body distinguishes self from non-self.

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