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Updated: Jun 5, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Surgery induced immunosuppression

Brian V Hogan1, Mark B Peter, Hrishikesh G Shenoy

  • 1Department of Surgery, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, United Kingdom. bvhogan@yahoo.co.uk

The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
|January 4, 2011
PubMed

Surgery and anaesthesia result in a variety of metabolic and endocrine responses, which result in a generalised state of immunosuppression in the immediate post-operative period. Surgery induced immunosuppression has been implicated in the development of post-operative septic complications and tumour metastasis formation. In addition the effectiveness of many treatments in the adjuvant setting is dependent on a functioning immune system. By understanding the mechanisms contributing to surgery-induced immunosuppression, surgeons may undertake strategies to minimise its effect and reduce potential short-term and long-term consequences to patients.

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