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Published on: July 10, 2014
Biomimetic dentin desensitizer based on nano-structured bioactive glass
John C Mitchell1, Lawrence Musanje, Jack L Ferracane
1Department of Restorative Dentistry, Division of Biomaterials and Biomechanics, Oregon Health & Science University, 611 SW Campus Drive, Portland, OR 97239, United States. mitchelj@ohsu.edu
Summary
A novel sol-gel bioactive glass effectively reduces dentinal fluid flow by occluding tubules. This material offers a durable solution for managing dentinal hypersensitivity.
Area of Science:
- Biomaterials Science
- Dental Research
- Materials Science
Background:
- Dentinal hypersensitivity is a common clinical condition.
- It is caused by fluid movement through dentinal tubules.
- Reducing dentinal fluid flow is a key therapeutic strategy.
Purpose of the Study:
- To evaluate a novel sol-gel bioactive glass for reducing dentinal fluid flow.
- To assess the efficacy of this bioactive glass in various carrier vehicles.
- To determine the potential of this material in managing dentinal hypersensitivity.
Main Methods:
- Cut tooth surfaces were treated with sol-gel bioactive glass particles in different carriers.
- Reduction in tubule fluid flow was measured.
- Surface analysis using Scanning Electron Microscopy (SEM) was performed.
- Durability was tested against brushing and acidic challenges.
- A non-bioactive glass was used for comparison.
Main Results:
- SEM confirmed tubular occlusion by the bioactive glass.
- A sustained reduction in hydrodynamic conductance was observed.
- The material demonstrated resistance to brushing and acidic conditions.
Conclusions:
- The novel sol-gel bioactive glass, when used with tested carriers, significantly reduces dentinal fluid flow.
- This material provides a durable effect.
- It holds promise for effectively reducing dentinal hypersensitivity.
