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Updated: Jun 5, 2026

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
Published on: May 27, 2016
Regulation of BCR signaling
1Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. kurosaki@rcai.riken.jp
Abstract:
B cells and antibodies are important elements of acquired humoral immunity in the fight against various pathogens, and signals through the B cell receptor (BCR) are crucial for the development, activation and differentiation of B cells. Our laboratory has focused on understanding the molecular mechanisms of BCR-mediated signaling cascades that regulate these processes in B cells. In this review, I will briefly present our studies that have clarified the molecular components of signaling cascades, mainly focusing on data using DT40 B cells and their genetic variants.
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