Jove
Visualize
Contact Us

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emergent Conformal Symmetry and Geometric Transport Properties of Quantum Hall States on Singular Surfaces.

Physical review letters·2017
Same author

Evaluation of potential salivary acetaldehyde production from ethanol in oral cancer patients and healthy subjects.

Hippokratia·2015
Same author

Effects of hyperbaric oxygen therapy on biochemical and histological parameters of muscle groups in proximity to the distracted rat tibia.

International journal of oral and maxillofacial surgery·2014
Same author

Fractional quantum Hall effect in a curved space: gravitational anomaly and electromagnetic response.

Physical review letters·2014
Same author

Cumulative effect of low-level laser therapy and low-intensity pulsed ultrasound on bone repair in rats.

International journal of oral and maxillofacial surgery·2014
Same author

Metadata management and semantics in microarray repositories.

Balkan journal of medical genetics : BJMG·2013
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 5, 2026

A Mouse Distraction Osteogenesis Model
04:24

A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

Soft tissue changes during distraction osteogenesis.

A Apaydin1, B Yazdirduyev, T Can

  • 1Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.

International Journal of Oral and Maxillofacial Surgery
|January 4, 2011
PubMed
Summary

Distraction osteogenesis in rabbits shows that longer distraction periods can lead to muscle fiber degeneration. Dividing bone distraction into stages may improve regeneration outcomes.

More Related Videos

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Related Experiment Videos

Last Updated: Jun 5, 2026

A Mouse Distraction Osteogenesis Model
04:24

A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Area of Science:

  • Oral and Maxillofacial Surgery
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Distraction osteogenesis is a surgical technique used to grow bone.
  • Understanding soft tissue adaptation is crucial for optimizing bone regeneration outcomes.
  • Varying distraction and consolidation periods significantly influence tissue response.

Purpose of the Study:

  • To investigate the effects of different distraction and consolidation periods on soft tissue changes during mandibular distraction osteogenesis.
  • To evaluate the histomorphometric changes in muscle tissue following varying distraction protocols.
  • To determine the optimal distraction strategy for enhanced bone regeneration.

Main Methods:

  • Mandibular distraction osteogenesis was performed on 15 male rabbits using a custom external device.
  • Animals were divided into three groups with distinct distraction periods (6, 11, and 16 days) and amounts (3mm, 5.5mm, 8mm).
  • Histomorphometric analysis using light microscopy was conducted to assess muscle fiber and nuclei changes.

Main Results:

  • Muscle fiber and nuclei count increased proportionally with the distraction period.
  • Shorter distraction periods (6 days) showed natural regeneration patterns.
  • Intermediate (11 days) and longer (16 days) distraction periods exhibited degeneration or a balance between regeneration and degeneration, respectively.

Conclusions:

  • Prolonged, continuous distraction in osteogenesis may lead to adverse soft tissue effects, including degeneration.
  • Dividing the total distraction into multiple, shorter periods is recommended for achieving better bone regeneration and minimizing tissue damage.
  • This staged approach to distraction osteogenesis could be a more effective strategy for significant bone augmentation.