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Type II transmembrane serine protease (TTSP) deregulation in cancer

Siobhan L Webb1, Andrew J Sanders, Malcolm D Mason

  • 1Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, UK, CF14 4XN. webbsl1@cf.ac.uk

Frontiers in Bioscience (Landmark Edition)
|January 4, 2011
PubMed

Insights

Type II transmembrane serine proteases (TTSPs) are key enzymes in cancer research. This review details their biological roles in human cancer development and progression, highlighting their significance.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Type II transmembrane serine proteases (TTSPs) are a recently identified enzyme family.
  • Advances in genome screening have facilitated TTSP identification and characterization.
  • TTSPs are implicated in diverse physiological functions, with ongoing discovery of new roles.

Purpose of the Study:

  • To review the current understanding of TTSP biological roles.
  • To focus on TTSPs identified in human cancer development and progression.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of data on TTSP function in cancer.
  • Synthesis of current knowledge on TTSP involvement in oncogenesis.

Main Results:

  • TTSPs are crucial in various physiological processes.
  • A significant number of TTSPs play critical roles in cancer initiation and advancement.
  • This review consolidates information on specific TTSPs implicated in human cancers.

Conclusions:

  • TTSPs represent a significant area of cancer research.
  • Understanding TTSP functions is vital for cancer therapy development.
  • Further research into TTSPs will likely uncover new therapeutic targets.

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