Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI.

eLife·2025
Same author

Leducq-funded network: calcification-omics, molecular elucidation, and therapeutics (COMET).

European heart journal·2025
Same author

Mineral Stress Drives Loss of Heterochromatin: An Early Harbinger of Vascular Inflammaging and Calcification.

Circulation research·2025
Same author

ECM Modifications Driven by Age and Metabolic Stress Directly Promote Vascular Smooth Muscle Cell Osteogenic Processes.

Arteriosclerosis, thrombosis, and vascular biology·2025
Same author

Interaction of poly dimethyl diallyl ammonium chloride with sludge components: Anaerobic digestion performance and adaptive changes of anaerobic microbes.

Water research·2024
Same author

Liver kinase B1: a master regulator of vascular smooth muscle cell fate and vascular metabolic homeostasis?

Cardiovascular research·2024
Same journal

Conditional Immortalization of Human Cardiac Fibroblasts for Pro-Fibrotic and Anti-Fibrotic Drug Screening.

Frontiers in bioscience (Landmark edition)·2026
Same journal

NF-κB Involvement in Glaucoma-Associated Neuroinflammation: Focus on Glial Cells.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Revealing the Molecular Network of Pattern-Triggered Immunity (PTI) Signal Transduction.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Decoding Immune Mechanisms in BCG-unresponsive Non-muscle Invasive Bladder Cancer.

Frontiers in bioscience (Landmark edition)·2026
Same journal

β-Ecdysterone Attenuates Ang II-Induced Senescence in Human Aortic Smooth Muscle Cells via Autophagy Activation and ROS Suppression Through AKT/mTOR Pathway Inhibition.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Exploration of the Role of M2 Macrophages in Hepatocellular Carcinoma: Insights into Disulfidptosis and Cellular Interactions.

Frontiers in bioscience (Landmark edition)·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Signalling pathways and vascular calcification.

Yiwen Liu1, Catherine M Shanahan

  • 1Cardiovascular Division, King's College London, 125 Coldharbour Lane SE5 9NU, London.

Frontiers in Bioscience (Landmark Edition)
|January 4, 2011
PubMed
Summary
This summary is machine-generated.

Vascular calcification, a risk factor for cardiovascular disease, involves complex signaling pathways. Understanding these pathways in vascular smooth muscle cells (VSMCs) is key to developing therapies for conditions like atherosclerosis and chronic kidney disease.

More Related Videos

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

Related Experiment Videos

Last Updated: Jun 5, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

Area of Science:

  • Cardiovascular Biology
  • Cell Signaling
  • Pathology

Background:

  • Vascular calcification significantly increases cardiovascular morbidity and mortality.
  • Current therapeutic strategies for vascular calcification are limited, highlighting a critical clinical need.
  • Pathological calcification is associated with atherosclerosis, chronic kidney disease, diabetes, and aging.

Purpose of the Study:

  • To review the initial triggers of vascular calcification across various disease contexts.
  • To examine the downstream signaling pathways that drive vascular calcification.
  • To explore the cross-talk between different signaling pathways involved in vascular calcification.

Main Methods:

  • Literature review focusing on signaling pathways in vascular calcification.
  • Analysis of common calcification triggers in different disease states.
  • Examination of the role of vascular smooth muscle cell (VSMC) phenotypic modulation.

Main Results:

  • Identified common initial triggers for vascular calcification in diverse pathologies.
  • Detailed the downstream signaling cascades initiating and propagating vascular calcification.
  • Highlighted the intricate cross-talk between various signaling networks.

Conclusions:

  • Understanding VSMC phenotypic modulation is crucial for addressing vascular calcification.
  • Elucidating signaling pathways offers potential therapeutic targets for preventing or reversing vascular calcification.
  • Comprehensive knowledge of these pathways is vital for managing cardiovascular risks associated with calcification.