Related Experiment Video
Updated: Jun 5, 2026

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice
Published on: January 24, 2025
Associations between adipokines and obesity-related cancer
Gilberto Paz-Filho1, Ee Lyn Lim, Ma-Li Wong
1Department of Translational Medicine, The John Curtin School of Medical Research, The Australian National University, Garran Rd, building 131, Canberra, Australia.
Abstract:
There is increasing evidence that obesity may have pathophysiological effects that extend beyond its well-known co-morbidities; in particular its role in cancer has received considerable epidemiological support. As adipose tissue becomes strongly established as an endocrine organ, two of its most abundant and most investigated adipokines, leptin and adiponectin, are also taken beyond their traditional roles in energy homeostasis, and are implicated as mediators of the effects of obesity on cancer development. This review examines these adipokines in relation to the prostate, breast, colorectal, thyroid, renal, pancreatic, endometrial and oesophageal cancers, and how they may orchestrate the influence of obesity on the development of these malignancies.
Related Concept Videos
Obesity
Psychoneuroimmunology: Diabetes and Cancer
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

