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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

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An Acupoint Catgut-embedding Therapy for Treating Obesity
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An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Obesity and thyroid cancer.

Tamara Mijovic1, Jacques How, Richard J Payne

  • 1Department of Otolaryngology and Head and Neck Surgery, McGill University, Montreal, Quebec, Canada.

Frontiers in Bioscience (Scholar Edition)
|January 4, 2011
PubMed
Summary
This summary is machine-generated.

Obesity significantly increases the risk of developing thyroid cancer in both men and women. This link is primarily explained by obesity-related hormonal imbalances, known as endocrinopathies.

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Area of Science:

  • Endocrinology
  • Oncology
  • Public Health

Background:

  • Rising global obesity rates present significant public health challenges.
  • While links between obesity and diseases like cardiovascular disease and diabetes are established, its role in cancer is increasingly recognized.

Purpose of the Study:

  • To review and synthesize the scientific evidence connecting obesity with an elevated risk of thyroid cancer.
  • To explore the biological mechanisms underlying this association.

Main Methods:

  • Literature review of studies investigating the relationship between obesity and thyroid cancer incidence.
  • Analysis of epidemiological data and biological plausibility.

Main Results:

  • Substantial evidence indicates a positive association between obesity and thyroid cancer risk.
  • This association is observed in both male and female populations.

Conclusions:

  • Obesity is a significant risk factor for developing thyroid cancer.
  • Obesity-related endocrinopathies are key biological mediators of this increased cancer risk.