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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Related Experiment Video

Updated: Jun 5, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Sarcomatoid renal cell carcinoma.

Kafil Akhtar1, Ahmad Shamshad, Zaheer Sufian

  • 1Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India. drkafilakhtar@gmail.com

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|January 4, 2011
PubMed
Summary

Sarcomatoid renal cell carcinoma, an aggressive variant, may originate from various kidney cancer types, not just clear cell carcinoma. This case report highlights a rare instance and successful treatment with interleukin-2 immunotherapy.

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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Published on: April 12, 2017

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Last Updated: Jun 5, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Area of Science:

  • Oncology
  • Pathology
  • Urology

Background:

  • Sarcomatoid renal cell carcinoma (SRCC) is an aggressive subtype of kidney cancer.
  • It is generally believed to arise from clear cell renal cell carcinoma.
  • However, evidence for SRCC originating from other renal cell carcinoma subtypes is limited.

Observation:

  • A 70-year-old male presented with acute left upper quadrant abdominal pain.
  • Pathological examination confirmed a diagnosis of sarcomatoid renal cell carcinoma.
  • The patient underwent treatment with high-dose interleukin-2 (IL-2) based immunotherapy.

Findings:

  • This case presents direct pathological evidence of SRCC.
  • The findings suggest SRCC may arise from a broader spectrum of renal cell carcinoma subtypes than previously assumed.
  • The patient achieved disease-free status six months post-surgery.

Implications:

  • This case expands the understanding of SRCC origins.
  • It underscores the potential for aggressive renal cell carcinoma variants to arise from diverse histological backgrounds.
  • Successful IL-2 immunotherapy in this case offers insights into treatment strategies for advanced SRCC.