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Clinicopathologic characteristics of CD99-positive diffuse large B-cell lymphoma
Sang Pyo Lee1, Sanghui Park, Jinny Park
1Department of Medicine, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.
Background:
CD99 immunoreactivity has been documented in a variety of tumors, including lymphoid malignancies such as anaplastic large-cell lymphomas. However, few studies have investigated the prognostic impact of CD99 in diffuse large B-cell lymphoma (DLBCL).
Methods:
Using conventional paraffin embedding, immunoperoxidase staining and tissue microarrays, we retrospectively investigated CD99 expression in 155 DLBCL patients.
Results:
Of the 155 DLBCL patients, 60 (38.7%) were positive for CD99. CD99 positivity was significantly associated with advanced stage (p < 0.01), higher risk group according to the International Prognostic Index risk score (p < 0.01) and non-germinal center B cell-like type (p = 0.01). The difference in progression-free survival (PFS) between CD99+ and CD99- groups was statistically significant (p = 0.04), even though the difference in overall survival was not (p = 0.74). Multivariate analysis demonstrated that CD99 expression was marginally correlated with PFS.
Conclusion:
To the best of our knowledge, this is the first report on the clinicopathologic characteristics of CD99+ DLBCL, particularly unique clinicopathologic features.
