Related Experiment Video
Updated: Jun 5, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
Fluoride concentration and pH of pediatric medicines regularly and long-term used by children
Isabela-Albuquerque Passos1, Cláudia-Helena-Soares de M Freitas, Fábio-Correia Sampaio
1Federal University of Paraíba, Rua José Firmino Ferreira, 1060/ 103, Bancários, João Pessoa, Paraíba, Brazil. isabelaapassos@yahoo.com.br
Objectives:
Our aim in this study was to determine the fluoride concentration and pH of 71 pediatric medicines regularly and long-term used by children.
Study Design:
The fluoride concentration was evaluated by selective electrode of fluoride (Orion). The pH was confronted using specific electrode (Orion) coupled to a potentiometer (Orion). The analyses were accomplished in duplicate. Pearson 's correlation and Kruskal-Wallis test were used. P-values below 5% were considered statistically significant.
Results:
Medicine pH averages±SD varied from 2.3±0.01 to up 10.6±0.02. Values below critical pH were observed in 42.25% (n=30) of presentations, with 25.35% (n=18) below 4.5 pH. Most medicines (84.5%) presented fluoride concentration below 0.05 mg/L.
Conclusions:
Among the pediatric medicines evaluated, this study has showed that 2-4 times-a-day posology and syrup formulations presented lowest pH and fluoride concentration, resulting in factors that predict highest cariogenic and erosive potential.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
Drug Dosing: Infants and Children
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmaceutical Poisoning: Potential Scenarios
