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Synthesis of Novel Functionalized 4-Aza-2,3-Didehydropodophyllotoxin Derivatives with Potential Antitumor Activity
Ajay Kumar1, Antonio E Alegria
1Department of Chemistry, University of Puerto Rico, Humacao, Puerto Rico.
Journal of Heterocyclic Chemistry
|January 4, 2011
Abstract:
Novel arylamino alcohols were synthesized and these alcohols were used to prepare 12 novel N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins, in one step, by simple reflux in ethanol. Isolated yields in the range of 50-70% were obtained.
