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Updated: Jun 5, 2026

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
Published on: March 2, 2016
Inflammation, HIF-1, and the epigenetics that follows
Claudio Brigati1, Barbara Banelli, Angela di Vinci
1Tumor Genetics Laboratory, National Institute for Cancer Research, Largo Benzi, 10, 16132 Genova, Italy.
Abstract:
We summarize recent findings linking inflammatory hypoxia to chromatin modifications, in particular to repressive histone signatures. We focus on the role of Hypoxia-Induced Factor-1 in promoting the activity of specific histone demethylases thus deeply modifying chromatin configuration. The consequences of these changes are depicted in terms of gene expression and cellular phenotypes. We finally integrate available data to introduce novel speculations on the relationship between inflammation, histones, and DNA function and integrity.
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