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A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
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Animal models of chronic pancreatitis

Makoto Otsuki1, Mitsuyoshi Yamamoto, Taizo Yamaguchi

  • 1Department of Lifestyle-related Diseases and Dietary Life, Graduate School of Life Science, Kobe Women's University, 2-1 Aoyama, Higashi-Suma, Suma-ku, Kobe 654-8585, Japan.

Gastroenterology Research and Practice
|January 4, 2011
PubMed

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Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
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