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Local antibiotic delivery with demineralized bone matrix
Christine S Lewis1, Peter R Supronowicz, Rasa M Zhukauskas
1Research and Development Group, RTI Biologics, 11621 Research Circle, Alachua, FL 32616, USA. clewis@rtix.com
Cell and Tissue Banking
|January 4, 2011
Summary
Human demineralized bone matrix (DBM) shows promise for treating bone infections by releasing antibiotics locally. This biodegradable material effectively delivers gentamicin without compromising its bone-healing properties.
Area of Science:
- Orthopedic surgery
- Biomaterials science
- Infectious disease treatment
Background:
- Infected nonunions require effective local antibiotic delivery.
- Current methods using non-biodegradable carriers necessitate a second surgery.
- Biodegradable antibiotic-impregnated materials are being explored for bone infection treatment.
Purpose of the Study:
- To investigate human demineralized bone matrix (DBM) as a carrier for local antibiotic delivery.
- To assess the gentamicin loading capacity and release kinetics of DBM.
- To evaluate the impact of antibiotic loading on DBM's osteoinductive properties.
Main Methods:
- Human demineralized bone matrix (DBM) was loaded with gentamicin.
- In vitro drug release studies were conducted over 13 days.
- Osteoinductivity of DBM was assessed in vitro and in vivo after antibiotic loading.
Main Results:
- DBM successfully loaded with gentamicin.
- Clinically relevant levels of gentamicin were released from DBM in vitro for at least 13 days.
- Antibiotic loading did not adversely affect the osteoinductive capacity of DBM.
Conclusions:
- Human demineralized bone matrix (DBM) is a viable osteoinductive and biodegradable material for local antibiotic delivery.
- DBM shows potential as a bone void filler for treating orthopedic infections.
- This approach may offer an alternative to non-biodegradable antibiotic carriers.
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