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Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction
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Valentin S Petrov1, Grigory V Osipov, Jürgen Kurths

  • 1Department of Control Theory, Nizhny Novgorod University, 23, Gagarin Avenue, 603950 Nizhny Novgorod, Russia. valentin.s.petrov@gmail.com

Chaos (Woodbury, N.Y.)
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Summary
This summary is machine-generated.

Cardiac fibroblasts significantly influence heart tissue electrical behavior. Their varying resting potentials can trigger spiral wave breakup or stabilize unstable waves in cardiac tissue models.

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Area of Science:

  • Computational Biology
  • Cardiac Electrophysiology
  • Biophysics

Background:

  • Cardiac tissue function relies on the coordinated electrical activity of myocytes.
  • Fibroblasts, a major cell type in cardiac tissue, are increasingly recognized for their role in electrical signaling.
  • The influence of fibroblast heterogeneity on cardiac electrophysiology remains incompletely understood.

Purpose of the Study:

  • To investigate the impact of fibroblasts with varying resting potentials on cardiac tissue electrophysiology.
  • To determine if fibroblast influence can alter cardiac tissue restitution properties.
  • To explore the role of fibroblasts in spiral wave dynamics, including breakup and stabilization.

Main Methods:

  • Development and simulation of a three-domain computational model of cardiac tissue (fibroblasts, myocytes, extracellular space).
  • Analysis of one-dimensional models to assess the effect of fibroblast resting potentials on tissue restitution.
  • Simulation of two-dimensional cardiac tissue slices to observe spiral wave behavior under fibroblast influence.

Main Results:

  • Fibroblasts with different resting potentials were shown to alter cardiac tissue restitution properties in one-dimensional models.
  • In two-dimensional simulations, fibroblast influence alone could induce spiral wave breakup.
  • Conversely, fibroblasts could stabilize initially unstable spiral waves, dependent on their resting potential values.

Conclusions:

  • Fibroblasts are not merely structural but active participants in cardiac electrical dynamics.
  • Fibroblast heterogeneity, specifically their resting potentials, plays a critical role in modulating cardiac arrhythmias.
  • Targeting fibroblast electrophysiology may offer novel therapeutic strategies for cardiac rhythm disorders.