Related Experiment Video
Updated: Jun 5, 2026

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction
Published on: January 16, 2014
Fibroblasts alter spiral wave stability
Valentin S Petrov1, Grigory V Osipov, Jürgen Kurths
1Department of Control Theory, Nizhny Novgorod University, 23, Gagarin Avenue, 603950 Nizhny Novgorod, Russia. valentin.s.petrov@gmail.com
Abstract:
We consider a three-domain model of cardiac tissue consisting of fibroblasts, myocytes, and extracellular space. We show in the one dimensional case that the fibroblasts with different resting potentials may alter restitution properties of tissue. On this basis we demonstrated that in two dimensional slice of cardiac tissue, a spiral wave break up can be caused purely by the influence of fibroblasts and, vice-versa, initially unstable spiral can be stabilized by fibroblasts depending on the value of their resting potential.
Related Concept Videos
Introduction to Fibroblasts
Microtubule Instability
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
Mechanism of Filopodia Formation
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Disassembly of Intermediate Filaments
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...
Determining the Plane of Cell Division
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...

