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Updated: Jun 5, 2026
Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach
Published on: December 1, 2011
Molecular epidemiological analysis of paired pol/env sequences from Portuguese HIV type 1 patients
Ana B Abecasis1, Andreia Martins, Inês Costa
1Centro de Malária e Outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Lisbon, Portugal. ana.abecasis@gmail.com
Abstract:
The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced. In this study, we have subtyped paired pol and env sequences from HIV-1 strains infecting 152 patients being clinically followed in Portugal. The percentage of strains in which we found discordant subtypes in pol and env was 25.7%. When the subtype in pol and env was concordant (65.1%), the most prevalent subtypes were subtype B (40.8%), followed by subtype C (17.8%) and subtype G (5.3%). The most prevalent recombinant form was CRF14_BGpol/Genv (7.2%).
