Related Experiment Video
Updated: Jun 5, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Effects of a calcium phosphate coating on the osseointegration of endosseous implants in a rabbit model
Filippo Fontana1, Isabella Rocchietta1, Alessandro Addis1
1Department of Implant Dentistry, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyDepartment of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyCRABCC - Reseach Center on Biotechnological Applications, Università degli studi di Milano, Milano, ItalyDepartment of Periodontics, School of dental Medicine, University of Pennsylvania, Philadelphia, PA, USAPrivate Practice, Pessano con Bornago, Milano, ItalyChairman, Department of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, Italy.
Objectives:
The aim of the present study was to evaluate a Ca-P coated implant surface in a rabbit model. The Ca-P surface (test) was compared to the titanium porous oxide surface (control) in terms of bone-to-implant contact (BIC) and removal torque value.
Materials And Methods:
Two hundred and sixteen dental implants were inserted in the tibia and in the femur of 36 rabbits. One hundred and eight were represented by Ca-P oxidized surface implant and other 108 were titanium porous oxide surface modified implants. Each rabbit received six implants. Animals were sacrificed after 2, 4 and 9 weeks of healing. Each group included 12 rabbits. The femoral implant and the proximal implant of the tibia of each animal were subjected to the histologic analysis and the distal implants of the tibia underwent removal torque test (RTQ).
Results:
Histological analysis in terms of BIC and RTQ did not revealed any significant difference between the Ca-P oxidized surface and the oxidized surface at 2 and 4 weeks. At 9 weeks, the oxidized surface demonstrated better results in terms of RTQ in the tibia.
Conclusion:
In conclusion, findings from the present study suggested that the Ca-P coating had no beneficial effect in improving bonding strength at the bone-implant interface either at 2, 4 and 9 weeks.
